Animations in Life Sciences
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Thursday 5 February 2015
Animations in Chemistry (Adobe Flash plugin is required)
Mechanism of the Mannich Reaction
Mechanism of the Strecker Synthesis
Mechanism of the Wittig Reaction
Isocitrate Dehydrogenase
The Class I Aldolase Reaction
Chymotrypsin Mechanism
SOurce http://www.sumanasinc.com/scienceinfocus/scienceinfocus.html
Mechanism of the Mannich Reaction
Mechanism of the Strecker Synthesis
Mechanism of the Wittig Reaction
Isocitrate Dehydrogenase
The Class I Aldolase Reaction
Chymotrypsin Mechanism
SOurce http://www.sumanasinc.com/scienceinfocus/scienceinfocus.html
References Books for CISR Life Sciences
LIFE SCIENCES |
|
Animal Physiology |
Guyton & Hall, Ganong, Moyes & Schulte, Chatterjee & Chatterjee |
Biochemistry |
Lehninger & Lubert stryer, Harper, Voet & Voet, Campbell, Biochemistry of nucleic acid – Adams, Knowler |
Biological Sciences |
Taylor |
Biotechnology |
B. D. Singh, Old Primrose, Click & Pasternak, Brown |
Cell Biology |
Gerald Karp, Bruce Alberts, Cooper & Hansman, De Robertis, Lordish & Baltimore |
Development Biology |
S. F. Gilbert |
Ecology |
P. D. Sharma, E. P. Odum, M. C. Dash, Kormondy |
Environmental Biology & Biodiversity |
Odum & Barret, Townsend & Harper, Smith & Smith, P. D. Sharma |
Evolution |
V.B.Rastogi, Veer bala |
Gene Cloning & DNA Analysis |
T. A. Brown |
Genetics |
Griffith , Gardner, Clug & Cummins, Lewin, Strickberger, Simmons & Snustad, |
Genome analysis |
Old and Primrose |
Immunology |
Kuby |
Medical Biochemistry |
Harper |
Microbiology |
Prescott & Harley, Madigan & Martinko, Pelczar |
Molecular biology |
Genes VIII, Voet & Voet, Baltimore, Lodish, Lehninger, Freifelder |
Plant physiology |
Taiz & Zeiger, William J. Hopkins, Salisbury & Ross, Devlin & Withan |
Plant Tissue Culture |
Bhojwani & Razdan |
Principles of Gene Manipulation & Genomics |
Primrose & Twyman |
Recombinant DNA |
Watson, Candy, Myers & Witkowski |
Taxonomy |
Subramanyam, Naik |
Technique Biophysical |
David Sheehan |
Techniques |
Wilson & N.Walker, Wilson & Goulding Upadhyay & Nath, David Freifelder |
CHEMISTRY |
|
1. Physical Chemistry |
(i) P.W. Atkins (ii) Puri, Sharma & Pathania (iii) K. L. Kapoor Vol. I to IV (iv) Barrow & Levine (v) Group Theory- F.A. Cotton (vi) Quantum Chemistry- Levine or R K Parsad |
2. Inorganic Chemistry |
(i) J. D. Lee (ii) Huheey (iii) Madan, Malik & Tuli –Selected topics (iv) Puri, Sharma, Kalia (v) Wilkinson & Cotton –Advanced Inorganic Chemistry |
3. Organic Chemistry |
(i) Claydden, Greeves, Warren, Worthers & Jerry March (ii) Carrey- Advanced organic Chemistry (iii) Morrison & Boyd (iv) Jagdamba Singh –Pericyclic reaction (v) Mukherjee & Singh –Reaction Mechanism (vi) Sanyal & Sanyal –Reactions, Reaarangements & Reagents (vii) Silver Stein,Y.R. Sharma –Spectroscopy (viii) P.S.Kalsi- Spectroscopy, Stereo chemistry (ix) Banwell- Spectroscopy (x) Coxon & Halton- Photo chemistry (xi) I. L. Finar Vol I & II |
PHYSICS
Atomic & Molecular Spectra |
Raj kumar,White |
Classical Mechanics |
Goldstein/J.C.Upadhyay Central forces – Goldstein Small Oscillation – Goldstein R.B.D. – Landon |
Electromagnetic Theory |
D.Griffiths/Satya Prakash/Chopra & Agrawal |
Electronics |
Millmann &Halkias/B.L.Thareja vol.4., Millmann &Grabell, Malvino, For Digital Electronics – Malvin & Leech |
Mathematical Physics |
Matrices – A.W.Joshi Complex variables – Schaum Series Vector calculation – Schaum Series Linear D.E. and other function –Shankara Rao/Any graduation book Miscellaneous: Arfkin/ Erwin Kreyszig / B.S.Grewal. |
Atomic & Molecular Spectra |
Banwell & Mc Cash, Raj Kumar |
Nuclear & Particle Physics |
D.C.Tayal, For Nuclear- Cohen, S.P.Patel For Particle-Griffith |
Quantum Mechanics |
Bransden & Joachain/H.C.Verma /Satya Prakash Cohen Tannudji or by Griffith |
Solid state Physics |
Kietal, Aschroft & Mermin, Decker |
Thermodynamics & Statistical Physics |
Sears & Salinger/Garg, Bansal & Ghosh/P. K. Chakraborty, F.Rief, Patharia |
MATHEMATICS
Modern Algebra |
A.R.Vasistha,I.N.Herstein, Khanna & S.K.Bhambri, R.Kumar, Gallian, Artin |
Complex Analysis |
Schaum Series, Kasana J.N.Sharma & A.R.Vasistha, Churchil,J.B. Conway |
Linear Algebra |
Schaum Series, G.Hadley & A.R.Vasistha, Hoffman & Kunze |
Matrices |
A.R.Vasistha, Schaum |
Operation Research |
S.D. Sharma, Kanti Swaroop, H.A.Taha, G.J.Lieberman |
Differential Equation |
Gupta & Kapoor, Schaum Series, Gun, Gupta&Dasgupta, Part I &II |
Discrete Mathematics |
Kolman, Busby & Ross, Trembly – Manohar, V.K. Balakrishan |
Number Theory |
Zuckerman, Burton |
Numerical Analysis |
S.S.Shastry, Jain, Lyenger & Jain, Erwin Kreyszig |
Integral Transform |
Krishna series, Erwin Kreyszig |
Higher Engineering Mathematics |
B.S.Grewal / Erwin Kreyszig |
Differential Geometry |
Krishna series |
Integral Equation |
Krishna series, M.D.Raisinghania |
Topology |
Krishna series, Simmons, J.N. Sharma, MUNKRES |
Functional Analysis |
Krishna series, Vasishtha & Sharma |
Mechanics |
Krishna series,Gupta &Gupta |
Real Analysis |
A.R.Vasistha, Arora & Malik, N.P.Bali, Apostol, W.Rudin, R.R.Goldbarg, Asha Rani Singhal |
Mathematical Analysis |
Arora & Malik, N.P.Bali, Rudin, Vasishtha, S.Bartle |
Calculus of variation |
M.D.Raisinghania,Silverman, Rober |
ODE- |
Erwin Kreyszig, Simmons |
PDE- |
Ian –Snedon, T.Amarnath |
About gate
The Graduate Aptitude Test in Engineering (GATE), is an All-India Examination conducted by the seven Indian Institutes of Technology and the Indian Institute of Science, Banglore, on behalf of the National Coordinating Board – GATE, Department of Education, Ministry of Human Resources Development (MHRD), Government of India.
Objective of GATE
The objective of GATE is to identify meritorious and motivated candidates for admission in Postgraduate Programs in Engineering at the national level. Some Engineering Colleges/Institutes specify GATE as a mandatory qualification for admission for Postgraduate Programs. For doing M.Tech. and Ph.D programme from IIT, IISc and other reputed institutes one should have GATE score. The GATE qualified students are given their all India Rank (also percentile). On the basis of this score students have to applied for different IITs or other insitutes.Eligibility
The following categories of candidates are eligible to appear in GATE:
1. Bachelor degree holders in Engineering/ Technology/ Architecture (4 years after 10+2) and those who are in the final or pre-final year of such programmes.2. Master degree holders in any branch of Science/ Mathematics/ Statistics/ Computer Applications or equivalent and those who are in the final or pre-final year of such programmes.
3. Candidates in the second or higher year of the Four-year Integrated Master degree programme (Post-B.Sc.) in Engineering/ Technology or in the third or higher year of Five-year Integrated Master degree programme and Dual Degree programme in Engineering/ Technology.
4. Candidates with qualifications obtained through examinations conducted by professional societies recognised by UPSC/AICTE (e.g. AMIE by IE(I), AMICE(I) by the Institute of Civil Engineers (India)-ICE(I)) as equivalent to B.E./B.Tech. Those who have completed section A or equivalent of such professional courses are also eligible.
Examination structure
The GATE examination consists of a single paper of 3 hours duration, which contains 65 questions carrying a maximum of 100 marks. The question paper will consist of only multiple choice objective questions. Each question will have four choices for the answer. The candidates will have to mark the correct choice on an Optical Response Sheet (ORS) by darkening the appropriate bubble against each question. There will be negative marking for each wrong answer, as explained in Question Paper Pattern.Chemistry SYLLABUS
Council of Scientific and Industrial Research
Human Resource Development Group
CHEMICAL SCIENCES
EXAM SCHEME
TIME: 3 HOURS MAXIMUM MARKS: 200
From June, 2011 CSIR- Exam for Award of Junior Research Fellowship shall be a Single Paper Test having Multiple Choice Questions (MCQs). The question paper is divided in three parts
Part ‘A’
This part shall carry 20 questions pertaining to General Science, Quantitative Reasoning & Analysis and Research Aptitude. The candidates shall be required to answer any 15 questions. Each question shall be of two marks. The total marks allocated to this section shall be 30 out of 200.
Part ‘B’
This part shall contain 50 Multiple Choice Questions(MCQs) generally covering the topics given in the syllabus. A candidate shall be required to answer any 35 questions. Each question shall be of two marks. The total marks allocated to this section shall be 70 out of 200.
Part ‘C’
This part shall contain 75 questions that are designed to test a candidate’s knowledge of scientific concepts and/or application of the scientific concepts. The questions shall be of analytical nature where a candidate is expected to apply the scientific knowledge to arrive at the solution to the given scientific problem. A candidate shall be required to answer any 25 questions. Each question shall be of four marks. The total marks allocated to this section shall be 100 out of 200.
� There will be negative marking @25% for each wrong answer. (not confirm)
� To enable the candidates to go through the questions, the question paper booklet shall be distributed 15 minutes before the scheduled time of the exam. The Answer sheet shall be distributed at the scheduled time of the exam.
� On completion of the exam i.e. at the scheduled closing time of the exam, the candidates shall be allowed to carry the Question Paper Booklet. No candidate is allowed to carry the Question Paper Booklet in case he/she chooses to leave the test before the scheduled closing time.
Inorganic Chemistry
1. Chemical periodicity
2. Structure and bonding in homo- and heteronuclear molecules, including shapes of molecules (VSEPR Theory).
3. Concepts of acids and bases, Hard-Soft acid base concept, Non-aqueous solvents.
4. Main group elements and their compounds: Allotropy, synthesis, structure and bonding, industrial importance of the compounds.
5. Transition elements and coordination compounds: structure, bonding theories, spectral and magnetic properties, reaction mechanisms.
6. Inner transition elements: spectral and magnetic properties, redox chemistry, analytical applications.
7. Organometallic compounds: synthesis, bonding and structure, and reactivity. Organometallics in homogeneous catalysis.
8. Cages and metal clusters.
9. Analytical chemistry- separation, spectroscopic, electro- and thermoanalytical methods.
10. Bioinorganic chemistry: photosystems, porphyrins, metalloenzymes, oxygen transport, electron- transfer reactions; nitrogen fixation, metal complexes in medicine.
11. Characterisation of inorganic compounds by IR, Raman, NMR, EPR, M�ssbauer, UV-vis, NQR, MS, electron spectroscopy and microscopic techniques.
12. Nuclear chemistry: nuclear reactions, fission and fusion, radio-analytical techniques and activation analysis.
Physical Chemistry:
1. Basic principles of quantum mechanics: Postulates; operator algebra; exactly-
solvable systems: particle-in-a-box, harmonic oscillator and the hydrogen atom, including shapes of atomic orbitals; orbital and spin angular momenta; tunneling.
2. Approximate methods of quantum mechanics: Variational principle; perturbation theory up to second order in energy; applications.
3. Atomic structure and spectroscopy; term symbols; many-electron systems and antisymmetry principle.
4. Chemical bonding in diatomics; elementary concepts of MO and VB theories; Huckel theory for conjugated p-electron systems.
5. Chemical applications of group theory; symmetry elements; point groups; character tables; selection rules.
6. Molecular spectroscopy: Rotational and vibrational spectra of diatomic molecules; electronic spectra; IR and Raman activities � selection rules; basic principles of magnetic resonance.
7. Chemical thermodynamics: Laws, state and path functions and their applications; thermodynamic description of various types of processes; Maxwell’s relations; spontaneity and equilibria; temperature and pressure dependence of thermodynamic quantities; Le Chatelier principle; elementary description of phase transitions; phase equilibria and phase rule; thermodynamics of ideal and non-ideal gases, and solutions.
8. Statistical thermodynamics: Boltzmann distribution; kinetic theory of gases; partition functions and their relation to thermodynamic quantities � calculations for model systems.
9. Electrochemistry: Nernst equation, redox systems, electrochemical cells; Debye-Huckel theory; electrolytic conductance � Kohlrausch’s law and its applications; ionic equilibria; conductometric and potentiometric titrations.
10. Chemical kinetics: Empirical rate laws and temperature dependence; complex reactions; steady state approximation; determination of reaction mechanisms; collision and transition state theories of rate constants; unimolecular reactions; enzyme kinetics; salt effects; homogeneous catalysis; photochemical reactions.
11. Colloids and surfaces: Stability and properties of colloids; isotherms and surface area; heterogeneous catalysis.
12. Solid state: Crystal structures; Bragg’s law and applications; band structure of solids.
13. Polymer chemistry: Molar masses; kinetics of polymerization.
14. Data analysis: Mean and standard deviation; absolute and relative errors; linear regression; covariance and correlation coefficient.
Organic Chemistry
1. IUPAC nomenclature of organic molecules including regio- and stereoisomers.
2. Principles of stereochemistry: Configurational and conformational isomerism in acyclic and cyclic compounds; stereogenicity, stereoselectivity, enantioselectivity, diastereoselectivity and asymmetric induction.
3. Aromaticity: Benzenoid and non-benzenoid compounds � generation and reactions.
4. Organic reactive intermediates: Generation, stability and reactivity of carbocations, carbanions, free radicals, carbenes, benzynes and nitrenes.
5. Organic reaction mechanisms involving addition, elimination and substitution reactions with electrophilic, nucleophilic or radical species. Determination of reaction pathways.
6. Common named reactions and rearrangements � applications in organic synthesis.
7. Organic transformations and reagents: Functional group interconversion including oxidations and reductions; common catalysts and reagents (organic, inorganic, organometallic and enzymatic). Chemo, regio and stereoselective transformations.
8. Concepts in organic synthesis: Retrosynthesis, disconnection, synthons, linear and convergent synthesis, umpolung of reactivity and protecting groups.
9. Asymmetric synthesis: Chiral auxiliaries, methods of asymmetric induction � substrate, reagent and catalyst controlled reactions; determination of enantiomeric and diastereomeric excess; enantio-discrimination. Resolution � optical and kinetic.
10. Pericyclic reactions � electrocyclisation, cycloaddition, sigmatropic rearrangements and other related concerted reactions. Principles and applications of photochemical reactions in organic chemistry.
11. Synthesis and reactivity of common heterocyclic compounds containing one or two heteroatoms (O, N, S).
12. Chemistry of natural products: Carbohydrates, proteins and peptides, fatty acids, nucleic acids, terpenes, steroids and alkaloids. Biogenesis of terpenoids and alkaloids.
13. Structure determination of organic compounds by IR, UV-Vis, 1H & 13C NMR and Mass spectroscopic techniques.
Interdisciplinary topics
1. Chemistry in nanoscience and technology.
2. Catalysis and green chemistry.
3. Medicinal chemistry.
4. Supramolecular chemistry.
5. Environmental chemistry.
Life Science SYLLABUS
Council of Scientific and Industrial Research
Human Resource Development Group
Examination Unit
EXAM SCHEME
TIME: 3 HOURS MAXIMUM MARKS: 200
From June, 2011 CSIR- Exam for Award of Junior Research Fellowship shall be a Single Paper Test having Multiple Choice Questions (MCQs). The question paper is divided in three parts
Part ‘A’
This part shall carry 20 questions pertaining to General Science, Quantitative Reasoning The candidates shall be required to answer any 15 questions. Each question shall be of two marks. The total marks allocated to this section shall be 30 out of 200.
Part ‘B’
This part shall contain 50 Multiple Choice Questions(MCQs) generally covering the topics given in the syllabus. A candidate shall be required to answer any 35 questions. Each question shall be of two marks. The total marks allocated to this section shall be 70 out of 200.
Part ‘C’
This part shall contain 75 questions that are designed to test a candidate’s knowledge of scientific concepts and/or application of the scientific concepts. The questions shall be of analytical nature where a candidate is expected to apply the scientific knowledge to arrive at the solution to the given scientific problem. A candidate shall be required to answer any 25 questions. Each question shall be of four marks. The total marks allocated to this section shall be 100 out of 200.
� There will be negative marking @25% for each wrong answer. for CISR
� To enable the candidates to go through the questions, the question paper booklet shall be distributed 15 minutes before the scheduled time of the exam. The Answer sheet shall be distributed at the scheduled time of the exam.
� On completion of the exam i.e. at the scheduled closing time of the exam, the candidates shall be allowed to carry the Question Paper Booklet. No candidate is allowed to carry the Question Paper Booklet in case he/she chooses to leave the test before the scheduled closing time.
1. Molecules and their Interaction Relevant to Biology
2. Cellular Organization
3. Fundamental Processes
4. Cell Communication and Cell Signaling
5. Developmental Biology
6. System Physiology � Plant
7. System Physiology � Animal
8. Inheritance Biology
9. Diversity of Life Forms
10. Ecological Principles
11. Evolution and Behavior
12. Applied Biology
13. Methods in Biology
1. MOLECULES AND THEIR INTERACTION RELAVENT TO BIOLOGY
A. Structure of atoms, molecules and chemical bonds.
B Composition, structure and function of biomolecules (carbohydrates, lipids,
proteins, nucleic acids and vitamins).
C. Stablizing interactions (Van der Waals, electrostatic, hydrogen bonding, hydrophobic
interaction, etc.).
D Principles of biophysical chemistry (pH, buffer, reaction kinetics, thermodynamics,
colligative properties).
E. Bioenergetics, glycolysis, oxidative phosphorylation, coupled reaction, group transfer, biological energy transducers.
F. Principles of catalysis, enzymes and enzyme kinetics, enzyme regulation, mechanism of
enzyme catalysis, isozymes
G. Conformation of proteins (Ramachandran plot, secondary structure, domains, motif
and folds).
H. Conformation of nucleic acids (helix (A, B, Z), t-RNA, micro-RNA).
I. Stability of proteins and nucleic acids.
J. Metabolism of carbohydrates, lipids, amino acids nucleotides and vitamins.
2. CELLULAR ORGANIZATION
A) Membrane structure and function
(Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis, ion channels, active transport, membrane pumps, mechanism of sorting and regulation of intracellular transport,electrical properties of membranes).
B) Structural organization and function of intracellular organelles (Cell wall, nucleus, mitochondria, Golgi bodies, lysosomes, endoplasmic reticulum, peroxisomes, plastids, vacuoles, chloroplast, structure & function of cytoskeleton and its role in motility).
C) Organization of genes and chromosomes (Operon, unique and repetitive DNA, interrupted genes, gene families, structure of chromatin and chromosomes, heterochromatin, euchromatin, transposons).
D) Cell division and cell cycle (Mitosis and meiosis, their regulation, steps in cell cycle, regulation and control of cell cycle).
E) Microbial Physiology (Growth yield and characteristics, strategies of cell division, stress response)
3. FUNDAMENTAL PROCESSES
A) DNA replication, repair and recombination (Unit of replication, enzymes involved, replication origin and replication fork, fidelity of replication, extrachromosomal replicons, DNA damage and repair mechanisms, homologous and site-specific recombination).
B) RNA synthesis and processing (transcription factors and machinery, formation of initiation complex, transcription activator and repressor, RNA polymerases, capping,
elongation, and termination, RNA processing, RNA editing, splicing, and polyadenylation, structure and function of different types of RNA, RNA transport).
C) Protein synthesis and processing (Ribosome, formation of initiation complex, initiation factors and their regulation, elongation and elongation factors, termination, genetic code, aminoacylation of tRNA, tRNA-identity, aminoacyl tRNA synthetase, and translational proof-reading, translational inhibitors, Post- translational modification of proteins).
D) Control of gene expression at transcription and translation level (regulating the expression of phages, viruses, prokaryotic and eukaryotic genes, role of chromatin in gene expression and gene silencing).
4. Cell communication and cell signaling
A) Host parasite interaction Recognition and entry processes of different pathogens like bacteria, viruses into animal and plant host cells, alteration of host cell behavior by pathogens, virus-induced cell transformation, pathogen-induced diseases in animals and plants, cell-cell fusion in both normal and abnormal cells.
B) Cell signaling Hormones and their receptors, cell surface receptor, signaling through G-protein coupled receptors, signal transduction pathways, second messengers, regulation of signaling pathways, bacterial and plant two-component systems, light signaling in plants, bacterial chemotaxis and quorum sensing.
C) Cellular communication Regulation of hematopoiesis, general principles of cell communication, cell adhesion and roles of different adhesion molecules, gap junctions, extracellular matrix, integrins, neurotransmission and its regulation.
D) Cancer
Genetic rearrangements in progenitor cells, oncogenes, tumor suppressor genes, cancer and the cell cycle, virus-induced cancer, metastasis, interaction of cancer cells with normal cells, apoptosis, therapeutic interventions of uncontrolled cell growth.
E) Innate and adaptive immune system Cells and molecules involved in innate
and adaptive immunity, antigens, antigenicity and immunogenicity. B and T cell epitopes, structure and function of antibody molecules. generation of antibody diversity, monoclonal antibodies, antibody engineering, antigen-antibody interactions, MHC molecules, antigen processing and presentation, activation and differentiation of B and T cells, B and T cell receptors, humoral and cell-mediated immune responses, primary and secondary immune modulation, the complement system, Toll-like receptors, cell-mediated effector functions, inflammation, hypersensitivity and autoimmunity, immune response during bacterial (tuberculosis), parasitic (malaria) and viral (HIV) infections, congenital and acquired immunodeficiencies, vaccines.
5. DEVELOPMENTAL BIOLOGY
A) Basic concepts of development : Potency, commitment, specification, induction, competence, determination and differentiation; morphogenetic gradients; cell fate and cell lineages; stem cells; genomic equivalence and the cytoplasmic determinants; imprinting; mutants and transgenics in analysis of development
B) Gametogenesis, fertilization and early development: Production of gametes, cell surface molecules in sperm-egg recognition in animals; embryo sac development and double fertilization in plants; zygote formation, cleavage, blastula formation, embryonic fields, gastrulation and formation of germ layers in animals; embryogenesis, establishment of symmetry in plants; seed formation and germination.
C) Morphogenesis and organogenesis in animals : Cell aggregation and differentiation in
Dictyostelium; axes and pattern formation in Drosophila, amphibia and chick; organogenesis � vulva formation in Caenorhabditis elegans, eye lens induction, limb development and regeneration in vertebrates; differentiation of neurons, post embryonic development- larval formation, metamorphosis; environmental regulation of normal development; sex determination.
D) Morphogenesis and organogenesis in plants: Organization of shoot and root apical meristem; shoot and root development; leaf development and phyllotaxy; transition to flowering, floral meristems and floral development in Arabidopsis and Antirrhinum
E) Programmed cell death, aging and senescence
6. SYSTEM PHYSIOLOGY – PLANT
A. Photosynthesis – Light harvesting complexes; mechanisms of electron transport; photoprotective mechanisms; CO2 fixation-C3, C4 and CAM pathways.
B. Respiration and photorespiration � Citric acid cycle; plant mitochondrial electron transport and ATP synthesis; alternate oxidase; photorespiratory pathway.
C. Nitrogen metabolism – Nitrate and ammonium assimilation; amino acid biosynthesis.
D. Plant hormones � Biosynthesis, storage, breakdown and transport; physiological effects and mechanisms of action.
E. Sensory photobiology – Structure, function and mechanisms of action of phytochromes, cryptochromes and phototropins; stomatal movement; photoperiodism and biological clocks.
F. Solute transport and photoassimilate translocation � uptake, transport and translocation of water, ions, solutes and macromolecules from soil, through cells, across membranes, through xylem and phloem; transpiration; mechanisms of loading and unloading of photoassimilates.
G. Secondary metabolites – Biosynthesis of terpenes, phenols and nitrogenous compounds and their roles.
H. Stress physiology � Responses of plants to biotic (pathogen and insects) and abiotic (water, temperature and salt) stresses.
7. SYSTEM PHYSIOLOGY – ANIMAL
A. Blood and circulation – Blood corpuscles, haemopoiesis and formed elements, plasma function, blood volume, blood volume regulation, blood groups, haemoglobin, immunity, haemostasis.
B. Cardiovascular System: Comparative anatomy of heart structure, myogenic heart, specialized tissue, ECG � its principle and significance, cardiac cycle, heart as a pump, blood pressure, neural and chemical regulation of all above.
C. Respiratory system – Comparison of respiration in different species, anatomical considerations, transport of gases, exchange of gases, waste elimination, neural and chemical regulation of respiration.
D. Nervous system – Neurons, action potential, gross neuroanatomy of the brain and spinal cord, central and peripheral nervous system, neural control of muscle tone and posture.
E. Sense organs – Vision, hearing and tactile response.
F. Excretory system – Comparative physiology of excretion, kidney, urine formation, urine concentration, waste elimination, micturition, regulation of water balance, blood volume, blood pressure, electrolyte balance, acid-base balance.
G. Thermoregulation – Comfort zone, body temperature � physical, chemical, neural regulation, acclimatization.
H. Stress and adaptation
I. Digestive system – Digestion, absorption, energy balance, BMR.
J. Endocrinology and reproduction – Endocrine glands, basic mechanism of hormone action, hormones and diseases; reproductive processes, gametogenesis, ovulation, neuroendocrine regulation
8. INHERITANCE BIOLOGY
A) Mendelian principles : Dominance, segregation, independent assortment.
B) Concept of gene : Allele, multiple alleles, pseudoallele, complementation tests
C) Extensions of Mendelian principles : Codominance, incomplete dominance, gene interactions, pleiotropy, genomic imprinting, penetrance and expressivity, phenocopy, linkage and crossing over, sex linkage, sex limited and sex influenced characters.
D) Gene mapping methods : Linkage maps, tetrad analysis, mapping with molecular markers, mapping by using somatic cell hybrids, development of mapping population in plants.
E) Extra chromosomal inheritance : Inheritance of Mitochondrial and chloroplast genes, maternal inheritance.
F) Microbial genetics : Methods of genetic transfers � transformation, conjugation, transduction and sex-duction, mapping genes by interrupted mating, fine structure analysis of genes.
G) Human genetics : Pedigree analysis, lod score for linkage testing, karyotypes, genetic disorders.
H) Quantitative genetics : Polygenic inheritance, heritability and its measurements, QTL mapping.
I) Mutation : Types, causes and detection, mutant types � lethal, conditional, biochemical, loss of function, gain of function, germinal verses somatic mutants, insertional mutagenesis.
J) Structural and numerical alterations of chromosomes : Deletion, duplication, inversion, translocation, ploidy and their genetic implications.
K) Recombination : Homologous and non-homologous recombination including transposition. 9. DIVERSITY OF LIFE FORMS:
A. Principles & methods of taxonomy:
Concepts of species and hierarchical taxa, biological nomenclature, classical & quantititative methods of taxonomy of plants, animals and microorganisms.
B. Levels of structural organization:
Unicellular, colonial and multicellular forms. Levels of organization of tissues, organs & systems. Comparative anatomy, adaptive radiation, adaptive modifications.
C. Outline classification of plants, animals & microorganisms:
Important criteria used for classification in each taxon. Classification of plants, animals and microorganisms. Evolutionary relationships among taxa.
D. Natural history of Indian subcontinent:
Major habitat types of the subcontinent, geographic origins and migrations of species. Comman Indian mammals, birds. Seasonality and phenology of the subcontinent.
E. Organisms of health & agricultural importance:
Common parasites and pathogens of humans, domestic animals and crops.
F. Organisms of conservation concern:
Rare, endangered species. Conservation strategies.
10. ECOLOGICAL PRINCIPLES
The Environment: Physical environment; biotic environment; biotic and abiotic interactions.
Habitat and Niche: Concept of habitat and niche; niche width and overlap; fundamental and realized niche; resource partitioning; character displacement.
Population Ecology: Characteristics of a population; population growth curves; population regulation; life history strategies (r and K selection); concept of metapopulation � demes and dispersal, interdemic extinctions, age structured populations.
Species Interactions: Types of interactions, interspecific competition, herbivory, carnivory, pollination, symbiosis.
Community Ecology: Nature of communities; community structure and attributes; levels of species diversity and its measurement; edges and ecotones.
Ecological Succession: Types; mechanisms; changes involved in succession; concept of climax.
Ecosystem Ecology: Ecosystem structure; ecosystem function; energy flow and mineral cycling (C,N,P); primary production and decomposition; structure and function of some Indian ecosystems: terrestrial (forest, grassland) and aquatic (fresh water, marine, eustarine).
Biogeography: Major terrestrial biomes; theory of island biogeography; biogeographical zones of India.
Applied Ecology: Environmental pollution; global environmental change; biodiversity: status, monitoring and documentation; major drivers of biodiversity change; biodiversity management approaches.
Conservation Biology: Principles of conservation, major approaches to management, Indian case studies on conservation/management strategy (Project Tiger, Biosphere reserves).
11. EVOLUTION AND BEHAVIOUR
A. Emergence of evolutionary thoughts
Lamarck; Darwin�concepts of variation, adaptation, struggle, fitness and natural selection; Mendelism; Spontaneity of mutations; The evolutionary synthesis.
B. Origin of cells and unicellular evolution:
Origin of basic biological molecules; Abiotic synthesis of organic monomers and polymers; Concept of Oparin and Haldane; Experiement of Miller (1953); The first cell; Evolution of prokaryotes; Origin of eukaryotic cells; Evolution of unicellular eukaryotes; Anaerobic metabolism, photosynthesis and aerobic metabolism.
C. Paleontology and Evolutionary History:
The evolutionary time scale; Eras, periods and epoch; Major events in the evolutionary
time scale; Origins of unicellular and multi cellular organisms; Major groups of plants and animals; Stages in primate evolution including Homo.
D. Molecular Evolution:
Concepts of neutral evolution, molecular divergence and molecular clocks; Molecular tools in phylogeny, classification and identification; Protein and nucleotide sequence analysis; origin of new genes and proteins; Gene duplication and divergence.
E. The Mechanisms:
Population genetics � Populations, Gene pool, Gene frequency; Hardy-Weinberg Law; concepts and rate of change in gene frequency through natural selection, migration and random genetic drift; Adaptive radiation; Isolating mechanisms; Speciation; Allopatricity and Sympatricity; Convergent evolution; Sexual selection; Co-evolution.
F. Brain, Behavior and Evolution:
Approaches and methods in study of behavior; Proximate and ultimate causation; Altruism and evolution-Group selection, Kin selection, Reciprocal altruism; Neural basis
of learning, memory, cognition, sleep and arousal; Biological clocks; Development
of behavior; Social communication; Social dominance; Use of space and territoriality;
Mating systems, Parental investment and Reproductive success; Parental care;Aggressive behavior; Habitat selection and optimality in foraging; Migration, orientation and navigation; Domestication and behavioral changes.
12. APPLIED BIOLOGY:
A. Microbial fermentation and production of small and macro molecules.
B. Application of immunological principles, vaccines, diagnostics. Tissue and cell culture methods for plants and animals.
C. Transgenic animals and plants, molecular approaches to diagnosis and strain identification.
D. Genomics and its application to health and agriculture, including gene therapy.
E. Bioresource and uses of biodiversity.
F. Breeding in plants and animals, including marker � assisted selection
G. Bioremediation and phytoremediation
H. Biosensors
13. METHODS IN BIOLOGY
A. Molecular Biology and Recombinant DNA methods: Isolation and purification of RNA , DNA (genomic and plasmid) and proteins, different separation methods. Analysis of RNA, DNA and proteins by one and two dimensional gel electrophoresis, Isoelectric focusing gels. Molecular cloning of DNA or RNA fragments in bacterial and eukaryotic systems. Expression of recombinant proteins using bacterial, animal and plant vectors. Isolation of specific nucleic acid sequences Generation of genomic and cDNA libraries in plasmid, phage, cosmid, BAC and YAC vectors. In vitro mutagenesis and deletion techniques, gene knock out in bacterial and eukaryotic organisms. Protein sequencing methods, detection of post translation modification of proteins. DNA sequencing methods, strategies for genome sequencing.Methods for analysis of gene expression at RNA and protein level, large scale expression, such as micro array based techniques Isolation, separation and analysis of carbohydrate and lipid molecules RFLP, RAPD and AFLP techniques
B. Histochemical and Immunotechniques
Antibody generation, Detection of molecules using ELISA, RIA, western blot,
immunoprecipitation, fluocytometry and immunofluorescence microscopy,
detection of molecules in living cells, in situ localization by techniques such as FISH
and GISH.
C Biophysical Method:
Molecular analysis using UV/visible, fluorescence, circular dichroism, NMR and ESR
spectroscopy Molecular structure determination using X-ray diffraction and NMR,
Molecular analysis using light scattering, different types of mass spectrometry and
surface plasma resonance methods.
D Statisitcal Methods:
Measures of central tendency and dispersal; probability distributions (Binomial, Poisson and normal); Sampling distribution; Difference between parametric and
non-parametric statistics; Confidence Interval; Errors; Levels of significance; Regression and Correlation; t-test; Analysis of variance; X2 test;; Basic introduction to Muetrovariate statistics, etc.
E. Radiolabeling techniques:
Detection and measurement of different types of radioisotopes normally used in biology, incorporation of radioisotopes in biological tissues and cells, molecular imaging of radioactive material, safety guidelines.
F. Microscopic techniques:
Visulization of cells and subcellular components by light microscopy, resolving powers
of different microscopes, microscopy of living cells, scanning and transmission
microscopes, different fixation and staining techniques for EM, freeze-etch and freeze-
fracture methods for EM, image processing methods in microscopy.
G. Electrophysiological methods:
Single neuron recording, patch-clamp recording, ECG, Brain activity recording, lesion
and stimulation of brain, pharmacological testing, PET, MRI, fMRI, CAT .
H. Methods in field biology:
Methods of estimating population density of animals and plants, ranging patterns
through direct, indirect and remote observations, sampling methods in the study of
behavior, habitat characterization: ground and remote sensing methods.
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